How Quercetin, Bromelain, and NAC Support Histamine Balance

Histamine response blog featuring quercetin, bromelain and NAC

Histamine plays a key role in the body’s immune response, but too much histamine—or poor clearance—can lead to uncomfortable symptoms. Itchy skin, sneezing, watery eyes, sinus pressure, and digestive sensitivity are often signs that histamine levels are out of balance.

That’s where specific nutrients like Quercetin, Bromelain, and NAC can help. These compounds work together to support histamine processing, reduce sensitivity, and promote immune comfort, especially during seasonal changes.

The Science Behind Histamine Regulation

Histamine is a compound released by the immune system in response to triggers like pollen, dust, certain foods, or environmental changes. The body typically breaks it down using enzymes, but some people struggle to clear it efficiently.

This can lead to histamine buildup and recurring symptoms. Supporting the body’s natural histamine breakdown and inflammatory response can help reduce flare-ups and discomfort.

Key Nutrients for Histamine Support

Quercetin

  • A natural bioflavonoid found in plants.
  • Acts as a mast cell stabilizer, helping reduce histamine release.
  • Supports immune modulation and reduces overreactions to environmental triggers.
  • Shown to ease symptoms like sneezing, runny nose, and itchy skin.

Bromelain 

  • A proteolytic enzyme extracted from pineapple stem.
  • Enhances absorption of quercetin, making it more effective.
  • Helps reduce inflammation and swelling in the sinuses and airways.
  • Supports healthy immune response during allergy seasons.

NAC (N-Acetylcysteine)

  • A powerful antioxidant and precursor to glutathione, the body’s master detoxifier.
  • Helps break down excess histamine and supports liver detox function.
  • Aids in clearing mucus and reducing congestion in the lungs and sinuses.

Why These Ingredients Work Together

Each of these nutrients plays a distinct role, but together they create a powerful formula to:

  • Limit excess histamine release.
  • Support histamine breakdown and detoxification.
  • Reduce inflammation linked to histamine intolerance.
  • Help manage seasonal sensitivity and allergy-like symptoms.

Granions Histamine Balance – Targeted Seasonal Support

Granions Histamine Balance combines clinical-strength Quercetin (570 mg), Bromelain (427.5 mg), and NAC (96 mg) with added Vitamin C, Immortelle extract, and Nettle leaf—all known to support immune function and mucosal health.

This formula is:

  • Vegan and preservative-free
  • Gentle enough for daily use
  • Designed for immune comfort and seasonal well-being

Whether you’re managing histamine-related symptoms or want extra support during allergy season, this blend supports your body’s natural balance.

How to Use

Take 1 capsule daily with food for maintenance. For more intensive support, take 2 to 3 capsules daily for 20 to 30 days. Suitable for adults and children over 5 (capsule can be opened and mixed with food if needed).

Histamine Balance from the Inside Out


When your body processes histamine effectively, you feel clearer, lighter, and more comfortable. The right nutritional support can make a noticeable difference.


Granions Histamine Balance is designed to help your body stay balanced—so you can breathe easier, react less, and feel better all season long